Design of a new peptidomimetic agonist for the melanocortin receptors based on the solution structure of the peptide ligand, Ac-Nle-cyclo[Asp-Pro-dPhe-Arg-Trp-Lys]-NH2

Targeted Disruption of the Melanocortin-4 Receptor Results in Obesity in Mice

Dennis Huszar, Catherine Lynch, Victoria Fairchild-Huntress et al. · Cell · 1997 · 3K citations · Full text

Medicine, Endocrinology, Neuroscience +11

Role of melanocortinergic neurons in feeding and the agouti obesity syndrome

Wei Fan, Bruce A. Boston, Robert A. Kesterson et al. · Nature · 1997 · 1.9K citations

Life Sciences, Neurobiology, Neuroscience +14

Exocrine Gland Dysfunction in MC5-R-Deficient Mice: Evidence for Coordinated Regulation of Exocrine Gland Function by Melanocortin Peptides

Wenbiao Chen, Michele A. Kelly, Ximena Opitz-Araya et al. · Cell · 1997 · 485 citations · Full text

Life Sciences, Endocrinology, Physiology +17

Adenosine 3‘,5‘-Monophosphate as the Intracellular Mediator of the Action of Adrenocorticotropic Hormone on the Adrenal Cortex

R.W. Butcher, Robert L. Ney, Earl W. Sutherland · Journal of Biological Chemistry · 1967 · 397 citations · Full text

Life Sciences, Endocrinology, Physiology +17

.alpha.-Melanotropin: the minimal active sequence in the frog skin bioassay

Victor J. Hruby, Brian C. Wilkes, Mac E. Hadley et al. · Journal of Medicinal Chemistry · 1987 · 274 citations

Medicine, Biochemistry, Pharmacology +7