Concepedia

Melanocortin System

The Melanocortin System is a neuroendocrine signaling network defined by the interaction of melanocortin peptides derived from proopiomelanocortin (POMC) with melanocortin receptors (MCRs), primarily regulating energy homeostasis, pigmentation, and inflammatory responses through G protein-coupled receptor-mediated pathways in the central nervous system and peripheral tissues.

3.2K

Publications

216.1K

Citations

12.4K

Authors

2.5K

Institutions

Publications per year

2017–2026

423

Parents

Publications

3.2K

Targeted Disruption of the Melanocortin-4 Receptor Results in Obesity in Mice

Dennis Huszar, Catherine Lynch, Victoria Fairchild-Huntress et al. · Cell · 1997 · 3K citations · Full text

, , +11

Role of melanocortinergic neurons in feeding and the agouti obesity syndrome

Wei Fan, Bruce A. Boston, Robert A. Kesterson et al. · Nature · 1997 · 1.9K citations

, , +14

Antagonism of Central Melanocortin Receptors in Vitro and in Vivo by Agouti-Related Protein

Michael M. Ollmann, Brent D. Wilson, Yingkui Yang et al. · Science · 1997 · 1.9K citations

, , +14

Clinical Spectrum of Obesity and Mutations in the Melanocortin 4 Receptor Gene

I. Sadaf Farooqi, Julia M. Keogh, Giles S.H. Yeo et al. · New England Journal of Medicine · 2003 · 1.8K citations · Full text

, , +16

The Cloning of a Family of Genes That Encode the Melanocortin Receptors

Kathleen G. Mountjoy, Linda S. Robbins, Marty Mortrud et al. · Science · 1992 · 1.6K citations

, , +14

1–5 of 3.2K

Authors

12.4K

  1. RD
    Roger D. Cone

    Oregon Health & Science University, United States

    73 publications · 19.8K citations

    53

    h-index

  2. VJ
    Victor J. Hruby

    University of Arizona, United States

    87 publications · 6.5K citations

    37

    h-index

  3. GS
    Gregory S. Barsh

    Stanford University, United States

    38 publications · 6.7K citations

    34

    h-index

  4. HB
    Helgi B. Schiöth

    Uppsala University, Sweden

    56 publications · 3.2K citations

    33

    h-index

  5. CH
    Carrie Haskell‐Luevano

    University of Florida, United States

    69 publications · 3.2K citations

    33

    h-index

1–5 of 12.4K

Institutions

2.5K

  1. Oregon Health & Science University

    Portland, United States

    58 h-index

    297 publications

    61.2K citations

  2. Uppsala University

    Uppsala, Sweden

    54 h-index

    397 publications

    22.4K citations

  3. Vollum Institute

    Portland, United States

    48 h-index

    179 publications

    61.6K citations

  4. Harvard University

    Cambridge, United States

    47 h-index

    266 publications

    58K citations

  5. University of Michigan

    Ann Arbor, United States

    43 h-index

    285 publications

    46.7K citations

  6. Centre National de la Recherche Scientifique

    Paris, France

    42 h-index

    372 publications

    18.3K citations

  7. Yale University

    New Haven, United States

    42 h-index

    173 publications

    25.9K citations

  8. Inserm

    Paris, France

    40 h-index

    418 publications

    28.7K citations

1–8 of 2.5K

Venues

  1. Endocrinology

    182 publications · 15.9K citations

    73

    h-index

  2. Proceedings of the National Academy of Sciences

    PNAS · 53 publications · 9.8K citations

    41

    h-index

  3. The Journal of Clinical Endocrinology & Metabolism

    JCEM · 66 publications · 5.3K citations

    38

    h-index

  4. Peptides

    112 publications · 3.9K citations

    37

    h-index

  5. Journal of Biological Chemistry

    JBC · 46 publications · 4.5K citations

    36

    h-index

1–5