Jodi Bradley

Molecular basis for the loss-of-function effects of the Alzheimer's disease–associated R47H variant of the immune receptor TREM2

Athena Sudom, Santosh Talreja, Jean Danao et al. · Journal of Biological Chemistry · 2018 · 154 citations · Full text

Life Sciences, Molecular Genetics, Neuroscience +17

Prior activation state shapes the microglia response to antihuman TREM2 in a mouse model of Alzheimer’s disease

Daniel C. Ellwanger, Shoutang Wang, Simone Brioschi et al. · Proceedings of the National Academy of Sciences · 2021 · 136 citations · Full text

Life Sciences, Neurobiology, Neuroscience +17

Discovery of AM-6494: A Potent and Orally Efficacious β-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitor with in Vivo Selectivity over BACE2

Liping H. Pettus, Matthew P. Bourbeau, Jodi Bradley et al. · Journal of Medicinal Chemistry · 2019 · 35 citations · Full text

Life Sciences, Medicinal Chemistry, Pharmacology +17

Discovery of 2-methylpyridine-based biaryl amides as γ-secretase modulators for the treatment of Alzheimer’s disease

Jian Jeffrey Chen, Wenyuan Qian, Kaustav Biswas et al. · Bioorganic & Medicinal Chemistry Letters · 2013 · 16 citations · Full text

Life Sciences, Medicinal Chemistry, Neuroscience +16