Molecular basis for the loss-of-function effects of the Alzheimer's disease–associated R47H variant of the immune receptor TREM2

Athena Sudom, Santosh Talreja, Jean Danao, +16

Journal of Biological Chemistry

TREM2-activating antibodies abrogate the negative pleiotropic effects of the Alzheimer's disease variant Trem2R47H on murine myeloid cell function

Qingwen Cheng, Jean Danao, Santosh Talreja, +11

Journal of Biological Chemistry

Structural and Mechanistic Regulation of the Pro-degenerative NAD Hydrolase SARM1

Matthew Bratkowski, Tian Xie, Desiree A. Thayer, +11

Cell Reports

Molecular RegulationMolecular BiologyCytoskeletonCellular PhysiologyMechanistic Regulation +17

Genetic Inactivation of Melanin-Concentrating Hormone Receptor Subtype 1 (MCHR1) in Mice Exerts Anxiolytic-Like Behavioral Effects

Madhuri Roy, Nadia K David, Jean Danao, +3

Neuropsychopharmacology

Behavioral NeuroscienceHormonal ReceptorFunctional SelectivityPhysiologyNeuroendocrine Mechanism +7

The G-Protein-Coupled Receptor GPR103 Regulates Bone Formation

Hélène Baribault, Jean Danao, Jamila Gupte, +4

Molecular and Cellular Biology

Molecular PharmacologySignal TransductionMolecular PhysiologyBone Morphogenic ProteinG Protein-coupled Receptor +13

Uncompetitive, adduct-forming SARM1 inhibitors are neuroprotective in preclinical models of nerve injury and disease

Matthew Bratkowski, Thomas C. Burdett, Jean Danao, +14

Neuron

Neuro-oncologyPreclinical ModelsMedicineNeuropharmacologyNerve Injury +8

G-protein-coupled receptor GPR21 knockout mice display improved glucose tolerance and increased insulin response

Jonitha Gardner, Sue Wu, Lei Ling, +5

Biochemical and Biophysical Research Communications

Metabolic SyndromeGlucose ToleranceInsulin SignalingMolecular PhysiologyG Protein-coupled Receptor +8

Discovery of Clinical Candidate 1-(4-(3-(4-(1<i>H</i>-Benzo[<i>d</i>]imidazole-2-carbonyl)phenoxy)pyrazin-2-yl)piperidin-1-yl)ethanone (AMG 579), A Potent, Selective, and Efficacious Inhibitor of Phosphodiesterase 10A (PDE10A)

Essa Hu, Ning Chen, Matthew P. Bourbeau, +20

Journal of Medicinal Chemistry

Clinical CandidatePharmacotherapyPde10a Clinical CandidatePharmaceutical ChemistryMedicinal Chemistry +15

Discovery and optimization of a series of liver X receptor antagonists

Xian‐Yun Jiao, David J. Kopecky, Ben Fisher, +12

Bioorganic & Medicinal Chemistry Letters

BiochemistryFunctional SelectivityMedicineLiver PhysiologyRational Drug Design +6

Discovery of a new binding mode for a series of liver X receptor agonists

David J. Kopecky, Xian Yun Jiao, Ben Fisher, +10

Bioorganic & Medicinal Chemistry Letters

Signal TransductionBiochemistryFunctional SelectivityMedicineLiver Physiology +7