Santosh Talreja

Molecular basis for the loss-of-function effects of the Alzheimer's disease–associated R47H variant of the immune receptor TREM2

Athena Sudom, Santosh Talreja, Jean Danao et al. · Journal of Biological Chemistry · 2018 · 154 citations · Full text

Life Sciences, Molecular Genetics, Neuroscience +17

TREM2-activating antibodies abrogate the negative pleiotropic effects of the Alzheimer's disease variant Trem2R47H on murine myeloid cell function

Qingwen Cheng, Jean Danao, Santosh Talreja et al. · Journal of Biological Chemistry · 2018 · 152 citations · Full text

Life Sciences, Cell Biology, Immunology +15

Uncompetitive, adduct-forming SARM1 inhibitors are neuroprotective in preclinical models of nerve injury and disease

Matthew Bratkowski, Thomas C. Burdett, Jean Danao et al. · Neuron · 2022 · 65 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +8

Discovery of Clinical Candidate 1-(4-(3-(4-(1<i>H</i>-Benzo[<i>d</i>]imidazole-2-carbonyl)phenoxy)pyrazin-2-yl)piperidin-1-yl)ethanone (AMG 579), A Potent, Selective, and Efficacious Inhibitor of Phosphodiesterase 10A (PDE10A)

Essa Hu, Ning Chen, Matthew P. Bourbeau et al. · Journal of Medicinal Chemistry · 2014 · 36 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +14

Rapid Identification of a Novel Small Molecule Phosphodiesterase 10A (PDE10A) Tracer

Essa Hu, Ji Ma, Christopher Biorn et al. · Journal of Medicinal Chemistry · 2012 · 28 citations · Full text

Medicine, Neuroscience, Pharmacology +9