A mouse model of human familial hypercholesterolemia: Markedly elevated low density lipoprotein cholesterol levels and severe atherosclerosis on a low-fat chow diet

Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells

Andrew Plump, Jonathan D. Smith, Tony Hayek et al. · Cell · 1992 · 2.3K citations

Life Sciences, Genetics, Molecular Genetics +10

Spontaneous Hypercholesterolemia and Arterial Lesions in Mice Lacking Apolipoprotein E

Sunny H. Zhang, Robert L. Reddick, Jorge A. Piedrahita et al. · Science · 1992 · 2.2K citations

Life Sciences, Cardiology, Genetics +17

ApoE-deficient mice develop lesions of all phases of atherosclerosis throughout the arterial tree.

Yutaka Nakashima, Andrew Plump, Elaine W. Raines et al. · Arteriosclerosis and Thrombosis A Journal of Vascular Biology · 1994 · 1.7K citations

Veterinary Medicine, Cardiology, Pathobiology +17

Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery.

S Ishibashi, Mark S. Brown, Joseph L. Goldstein et al. · Journal of Clinical Investigation · 1993 · 1.6K citations · Full text

Life Sciences, Molecular Genetics, Pharmacology +16

Generation of mice carrying a mutant apolipoprotein E gene inactivated by gene targeting in embryonic stem cells.

Jorge A. Piedrahita, S H Zhang, John R. Hagaman et al. · Proceedings of the National Academy of Sciences · 1992 · 926 citations

Life Sciences, Genetics, Molecular Genetics +10