Andrew Plump

Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells

Andrew Plump, Jonathan D. Smith, Tony Hayek et al. · Cell · 1992 · 2.2K citations

Metabolic Syndrome, Lipid Disorder, Oxysterol +12

ApoE-deficient mice develop lesions of all phases of atherosclerosis throughout the arterial tree.

Yutaka Nakashima, Andrew Plump, Elaine W. Raines et al. · Arteriosclerosis and Thrombosis A Journal of Vascular Biology · 1994 · 1.7K citations

Vascular Disease, Apoe-deficient Mice, Pathology +20

Upregulation of VCAM-1 and ICAM-1 at Atherosclerosis-Prone Sites on the Endothelium in the ApoE-Deficient Mouse

Yutaka Nakashima, Elaine W. Raines, Andrew Plump et al. · Arteriosclerosis Thrombosis and Vascular Biology · 1998 · 904 citations

Human apolipoprotein A-I gene expression increases high density lipoprotein and suppresses atherosclerosis in the apolipoprotein E-deficient mouse.

Andrew Plump, Charles Scott, Jan L. Breslow · Proceedings of the National Academy of Sciences · 1994 · 570 citations · Full text

Vascular Disease, Genetics, Apolipoprotein E-deficient Mouse +19

Disruption of the HNF-4 gene, expressed in visceral endoderm, leads to cell death in embryonic ectoderm and impaired gastrulation of mouse embryos.

W S Chen, Katia Manova, Daniel C. Weinstein et al. · Genes & Development · 1994 · 558 citations · Full text

Tissue Development, Developmental Biology, Visceral Endoderm +14