Mark S. Brown

Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery.

S Ishibashi, Mark S. Brown, Joseph L. Goldstein et al. · Journal of Clinical Investigation · 1993 · 1.6K citations · Full text

Life Sciences, Molecular Genetics, Pharmacology +16

NPXY, a sequence often found in cytoplasmic tails, is required for coated pit-mediated internalization of the low density lipoprotein receptor.

Wei J. Chen, J L Goldstein, Mark S. Brown · Journal of Biological Chemistry · 1990 · 944 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +16

The estradiol-stimulated lipoprotein receptor of rat liver. A binding site that membrane mediates the uptake of rat lipoproteins containing apoproteins B and E.

E. Windler, Petri T. Kovanen, Y S Chao et al. · Journal of Biological Chemistry · 1980 · 461 citations · Full text

Life Sciences, Biochemistry, Endocrinology +15

The two-receptor model of lipoprotein clearance: tests of the hypothesis in "knockout" mice lacking the low density lipoprotein receptor, apolipoprotein E, or both proteins.

Shun Ishibashi, Joachim Herz, N Maeda et al. · Proceedings of the National Academy of Sciences · 1994 · 422 citations

Life Sciences, Biochemistry, Molecular Biology +12

Nuclear protein that binds sterol regulatory element of low density lipoprotein receptor promoter. I. Identification of the protein and delineation of its target nucleotide sequence

Michael R. Briggs, Chieko Yokoyama, Xiaodong Wang et al. · Journal of Biological Chemistry · 1993 · 398 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17