PI3K/Akt-sensitive MEK-independent compensatory circuit of ERK activation in ER-positive PI3K-mutant T47D breast cancer cells

Genomic signatures to guide the use of chemotherapeutics

Anil Potti, Holly K. Dressman, Andrea Bild et al. · Nature Medicine · 2006 · 594 citations

Medicine, Molecular Biology, Oncology +11

<i>In vivo</i> Antitumor Activity of MEK and Phosphatidylinositol 3-Kinase Inhibitors in Basal-Like Breast Cancer Models

Klaus P. Hoeflich, Carol O’Brien, Zachary Boyd et al. · Clinical Cancer Research · 2009 · 473 citations

Medicine, Oncology, Pharmacology +17

MEK inhibitors: The chemistry and biological activity of U0126, its analogs, and cyclization products

John V. Duncia, Joseph B. Santella, C. Anne Higley et al. · Bioorganic & Medicinal Chemistry Letters · 1998 · 406 citations · Full text

Life Sciences, Biochemistry, Pharmacology +11

Basal Subtype and MAPK/ERK Kinase (MEK)-Phosphoinositide 3-Kinase Feedback Signaling Determine Susceptibility of Breast Cancer Cells to MEK Inhibition

Olga K. Mirzoeva, Debopriya Das, Laura M. Heiser et al. · Cancer Research · 2009 · 389 citations · Full text

Medicine, Cancer Biology, Oncology +17

Identification of Regulatory Phosphorylation Sites in Mitogen-activated Protein Kinase (MAPK)-activated Protein Kinase-1a/p90 That Are Inducible by MAPK

Kevin N. Dalby, Nick Morrice, F. Barry Caudwell et al. · Journal of Biological Chemistry · 1998 · 371 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +13