Boris Ν. Kholodenko

Signaling switches and bistability arising from multisite phosphorylation in protein kinase cascades

Nick I. Markevich, Jan B. Hoek, Boris Ν. Kholodenko · The Journal of Cell Biology · 2004 · 714 citations · Full text

Negative feedback and ultrasensitivity can bring about oscillations in the mitogen‐activated protein kinase cascades

Boris Ν. Kholodenko · European Journal of Biochemistry · 2000 · 655 citations · Full text

Quantification of Short Term Signaling by the Epidermal Growth Factor Receptor

Boris Ν. Kholodenko, Oleg V. Demin, Gisela Moehren et al. · Journal of Biological Chemistry · 1999 · 637 citations · Full text

Untangling the wires: A strategy to trace functional interactions in signaling and gene networks

Boris Ν. Kholodenko, Anatoly Kiyatkin, Frank J. Bruggeman et al. · Proceedings of the National Academy of Sciences · 2002 · 433 citations · Full text

Genetics, Molecular Biology, Network Analysis +21

The Mammalian MAPK/ERK Pathway Exhibits Properties of a Negative Feedback Amplifier

Oliver Sturm, Richard Orton, Joan Grindlay et al. · Science Signaling · 2010 · 250 citations · Full text