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Hypomorphic Mutation of PDK1 Suppresses Tumorigenesis in PTEN+/− Mice

José R. Bayascas, Nicholas R. Leslie, Ramon Parsons, Stewart Fleming, Dario R. Alessi

Current Biology · 2005 · 145 citations · 18 references

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18

The Tumor Suppressor, PTEN/MMAC1, Dephosphorylates the Lipid Second Messenger, Phosphatidylinositol 3,4,5-Trisphosphate

Tomohiko Maehama, Jack E. Dixon · Journal of Biological Chemistry · 1998 · 3.1K citations · Full text

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Negative Regulation of PKB/Akt-Dependent Cell Survival by the Tumor Suppressor PTEN

Vuk Stambolic, Akira Suzuki, José Luís de la Pompa et al. · Cell · 1998 · 2.6K citations · Full text

, , +16

Pten is essential for embryonic development and tumour suppression

Antonio Di Cristofano, Bárbara Pesce, Carlos Cordon‐Cardo et al. · Nature Genetics · 1998 · 1.5K citations

, , +14

The lipid phosphatase activity of PTEN is critical for its tumor supressor function

Michael P. Myers, Ian Pass, Ian H. Batty et al. · Proceedings of the National Academy of Sciences · 1998 · 1.2K citations

, , +15

Placental-specific IGF-II is a major modulator of placental and fetal growth

Miguel Constância, Myriam Hemberger, Jennifer Hughes et al. · Nature · 2002 · 1.1K citations

, , +15