Concepedia

Hypomorphic Alleles

Hypomorphic Alleles is a type of allelic interaction characterized by a partial loss of gene function, resulting in reduced expression or activity of the gene product compared to the wild-type allele.

487

Publications

35.7K

Citations

3.6K

Authors

1K

Institutions

Publications per year

2017–2026

99

Variants

Hypomorphs

Parents

Publications

487

Expression of recessive alleles by chromosomal mechanisms in retinoblastoma

Webster K. Cavenee, Thaddeus P. Dryja, Robert A. Phillips et al. · Nature · 1983 · 1.9K citations

, , +14

A Mutant <i>Drosophila</i> Insulin Receptor Homolog That Extends Life-Span and Impairs Neuroendocrine Function

Marc Tatar, A. H. Kopelman, Diane Epstein et al. · Science · 2001 · 1.6K citations

, , +17

The action of <i>ARGONAUTE1</i> in the miRNA pathway and its regulation by the miRNA pathway are crucial for plant development

Hervé Vaucheret, Franck Vazquez, Patrice Crété et al. · Genes & Development · 2004 · 1K citations · Full text

, , +17

Mouse intraflagellar transport proteins regulate both the activator and repressor functions of Gli transcription factors

Aimin Liu, Baolin Wang, Lee Niswander · Development · 2005 · 536 citations

, , +17

Functional polycystin-1 dosage governs autosomal dominant polycystic kidney disease severity

Katharina Hopp, Christopher J. Ward, Cynthia J. Hommerding et al. · Journal of Clinical Investigation · 2012 · 451 citations · Full text

, , +16

1–5 of 487

Authors

3.6K

  1. JR
    James R. Lupski

    Baylor College of Medicine, United States

    5 publications · 446 citations

    5

    h-index

  2. BB
    Bruce Beutler

    Scripps Research Institute, United States

    5 publications · 226 citations

    5

    h-index

  3. NW
    Nan Wu

    Chinese Academy of Medical Sciences & Peking Union Medical College, China

    4 publications · 424 citations

    4

    h-index

  4. BP
    Boris Pasche

    Wake Forest University, United States

    4 publications · 131 citations

    4

    h-index

  5. EM
    Eva Marie Y. Moresco

    The University of Texas Southwestern Medical Center, United States

    4 publications · 174 citations

    4

    h-index

1–5 of 3.6K

Institutions

1K

  1. Howard Hughes Medical Institute

    Chevy Chase, United States

    22 h-index

    75 publications

    11.1K citations

  2. Inserm

    Paris, France

    20 h-index

    138 publications

    9.7K citations

  3. National Institutes of Health

    Bethesda, United States

    16 h-index

    58 publications

    4.1K citations

  4. Harvard University

    Cambridge, United States

    15 h-index

    74 publications

    6.7K citations

  5. Centre National de la Recherche Scientifique

    Paris, France

    14 h-index

    67 publications

    4.8K citations

  6. Baylor College of Medicine

    Houston, United States

    13 h-index

    47 publications

    3K citations

  7. University of Michigan

    Ann Arbor, United States

    12 h-index

    39 publications

    3.3K citations

  8. Jackson Laboratory

    Bar Harbor, United States

    11 h-index

    34 publications

    1.5K citations

1–8 of 1K

Venues

  1. Development

    38 publications · 4K citations

    33

    h-index

  2. Genetics

    47 publications · 2.2K citations

    31

    h-index

  3. Human Molecular Genetics

    27 publications · 2.2K citations

    24

    h-index

  4. Proceedings of the National Academy of Sciences

    PNAS · 20 publications · 2.8K citations

    18

    h-index

  5. PLoS ONE

    19 publications · 791 citations

    17

    h-index

1–5