Synthesis and bioevaluation of a series of α-pyrone derivatives as potent activators of Nrf2/ARE pathway (part I)

Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants

Albena T. Dinkova‐Kostova, W. David Holtzclaw, Robert N. Cole et al. · Proceedings of the National Academy of Sciences · 2002 · 1.9K citations · Full text

Life Sciences, Biochemistry, Molecular Biology +16

Curcumin activates the haem oxygenase-1 gene via regulation of Nrf2 and the antioxidant-responsive element

Elisabeth Abidemi Balogun, Martha Hoque, Pengfei Gong et al. · Biochemical Journal · 2003 · 1K citations · Full text

Life Sciences, Biochemistry, Pharmacology +17

Heme oxygenase: A novel target for the modulation of inflammatory response

Dean Willis, Adrian Moore, Ronnie O. Frederick et al. · Nature Medicine · 1996 · 785 citations

Life Sciences, Biochemistry, Immunology +16

An inducible mouse model of colon carcinogenesis for the analysis of sporadic and inflammation-driven tumor progression

Clemens Neufert, Christoph Becker, Markus F. Neurath · Nature Protocols · 2007 · 680 citations

Medicine, Cancer Biology, Oncology +16

Pharmacodynamic characterization of chemopreventive triterpenoids as exceptionally potent inducers of Nrf2-regulated genes

Melinda S. Yates, Masafumi Tauchi, Fumiki Katsuoka et al. · Molecular Cancer Therapeutics · 2007 · 293 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +17