Zhengyu Jiang

Discovery of a Keap1-dependent peptide PROTAC to knockdown Tau by ubiquitination-proteasome degradation pathway

Mengchen Lu, Tian Liu, Qiong Jiao et al. · European Journal of Medicinal Chemistry · 2018 · 277 citations · Full text

Protein Function, Biochemistry, Protein Assembly +11

Discovery of Potent Keap1–Nrf2 Protein–Protein Interaction Inhibitor Based on Molecular Binding Determinants Analysis

Zhengyu Jiang, Mengchen Lu, Lili Xu et al. · Journal of Medicinal Chemistry · 2014 · 245 citations · Full text

Azo-PROTAC: Novel Light-Controlled Small-Molecule Tool for Protein Knockdown

Yuhui Jin, Mengchen Lu, Yan Wang et al. · Journal of Medicinal Chemistry · 2020 · 160 citations

Persistent Issues, Photochemistry, Biochemistry +15

CPUY192018, a potent inhibitor of the Keap1-Nrf2 protein-protein interaction, alleviates renal inflammation in mice by restricting oxidative stress and NF-κB activation

Mengchen Lu, Jing Zhao, Yuting Liu et al. · Redox Biology · 2019 · 135 citations · Full text

An inhibitor of the Keap1-Nrf2 protein-protein interaction protects NCM460 colonic cells and alleviates experimental colitis

Mengchen Lu, Jianai Ji, Yong-Lin Jiang et al. · Scientific Reports · 2016 · 112 citations · Full text