Decreased IRS-2 and Increased SREBP-1c Lead to Mixed Insulin Resistance and Sensitivity in Livers of Lipodystrophic and ob/ob Mice

Disruption of IRS-2 causes type 2 diabetes in mice

Dominic J. Withers, Julio Sanchez Gutierrez, Heather Towery et al. · Nature · 1998 · 1.8K citations

Life Sciences, Endocrinology, Molecular Biology +12

Loss of Insulin Signaling in Hepatocytes Leads to Severe Insulin Resistance and Progressive Hepatic Dysfunction

M.Dodson Michael, Rohit Kulkarni, Catherine Postic et al. · Molecular Cell · 2000 · 1.2K citations · Full text

Medicine, Cell Biology, Endocrinology +17

A Muscle-Specific Insulin Receptor Knockout Exhibits Features of the Metabolic Syndrome of NIDDM without Altering Glucose Tolerance

Jens C. Brüning, M.Dodson Michael, Jonathon N. Winnay et al. · Molecular Cell · 1998 · 1.2K citations · Full text

Medicine, Endocrinology, Molecular Genetics +14

Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy

Iichiro Shimomura, Robert E. Hammer, Shinji Ikemoto et al. · Nature · 1999 · 1.1K citations

Medicine, Biochemistry, Endocrinology +13

ADD1/SREBP1 promotes adipocyte differentiation and gene expression linked to fatty acid metabolism.

Jae Bum Kim, Bruce M. Spiegelman · Genes & Development · 1996 · 1K citations · Full text

Life Sciences, Biochemistry, Cell Biology +17