M S Brown

ER Stress Induces Cleavage of Membrane-Bound ATF6 by the Same Proteases that Process SREBPs

Jin Ye, Robert B. Rawson, Ryutaro Komuro et al. · Molecular Cell · 2000 · 1.8K citations · Full text

Protein Secretion, Protein Function, Signal Transduction +13

Multivalent feedback regulation of HMG CoA reductase, a control mechanism coordinating isoprenoid synthesis and cell growth.

M S Brown, J L Goldstein · Journal of Lipid Research · 1980 · 1.2K citations · Full text

Decreased IRS-2 and Increased SREBP-1c Lead to Mixed Insulin Resistance and Sensitivity in Livers of Lipodystrophic and ob/ob Mice

Iichiro Shimomura, Morihiro Matsuda, Robert E. Hammer et al. · Molecular Cell · 2000 · 828 citations

Metabolic Syndrome, Health Sciences, Biochemistry +13

Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a.

Hitoshi Shimano, Jay D. Horton, Robert E. Hammer et al. · Journal of Clinical Investigation · 1996 · 815 citations · Full text

Fatty Liver Disease, Transgenic Mice, Cellular Physiology +22

Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cells.

Iichiro Shimomura, Hitoshi Shimano, Jay D. Horton et al. · Journal of Clinical Investigation · 1997 · 754 citations · Full text

Exons 1A, Molecular Regulation, Insulin Signaling +18