A Muscle-Specific Insulin Receptor Knockout Exhibits Features of the Metabolic Syndrome of NIDDM without Altering Glucose Tolerance

Disruption of IRS-2 causes type 2 diabetes in mice

Dominic J. Withers, Julio Sanchez Gutierrez, Heather Towery et al. · Nature · 1998 · 1.8K citations

Life Sciences, Endocrinology, Molecular Biology +12

Insulin Resistance and Insulin Secretory Dysfunction as Precursors of Non-Insulin-Dependent Diabetes Mellitus: Prospective Studies of Pima Indians

Stephen Lillioja, David M. Mott, Maximilian Spraul et al. · New England Journal of Medicine · 1993 · 1.5K citations · Full text

Medicine, Endocrinology, Diabetology +14

Deletion of a DNA Polymerase β Gene Segment in T Cells Using Cell Type-Specific Gene Targeting

Hua Gu, Jamey D. Marth, Paul C. Orban et al. · Science · 1994 · 1.4K citations

Life Sciences, Genetics, Molecular Genetics +17

Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene

Eiichi Araki, Myra A. Lipes, Mary‐Elizabeth Patti et al. · Nature · 1994 · 1.3K citations

Life Sciences, Endocrinology, Molecular Biology +17

Role of glucose and insulin resistance in development of type 2 diabetes mellitus: results of a 25-year follow-up study

Blaise C. Martin, James H. Warram, Andrzej S. Królewski et al. · The Lancet · 1992 · 1.2K citations

Medicine, Endocrinology, Diabetology +11