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Inhibition of herpes proteases and antiviral activity of 2-substituted thieno[2,3-d]oxazinones

Richard L. Jarvest, Ivan L. Pinto, Stephen Ashman, Christine Dabrowski, Annabellee V. Fernandez, L. J. JENNINGS, Patrick Lavery, David G. Tew

Bioorganic & Medicinal Chemistry Letters · 1999 · 78 citations · 11 references

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11

The herpes simplex virus 1 gene encoding a protease also contains within its coding domain the gene encoding the more abundant substrate

F Y Liu, Bernard Roizman · Journal of Virology · 1991 · 223 citations · Full text

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The protease of herpes simplex virus type 1 is essential for functional capsid formation and viral growth

Min Gao, L Matusick-Kumar, Warren Hurlburt et al. · Journal of Virology · 1994 · 207 citations · Full text

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Design and synthesis of monocyclic β-lactams as mechanism-based inhibitors of human cytomegalovirus protease

Alan D. Borthwick, Gordon G. Weingarten, Terry Haley et al. · Bioorganic & Medicinal Chemistry Letters · 1998 · 168 citations · Full text

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A new serine-protease fold revealed by the crystal structure of human cytomegalovirus protease

Liang Tong, Chungeng Qian, Marie-Josée Massariol et al. · Nature · 1996 · 157 citations

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Structure of the Human Cytomegalovirus Protease Catalytic Domain Reveals a Novel Serine Protease Fold and Catalytic Triad

Ping Chen, Hideaki Tsuge, Robert J. Almassy et al. · Cell · 1996 · 150 citations · Full text

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