Richard L. Jarvest

Selection of an oral prodrug (BRL 42810; famciclovir) for the antiherpesvirus agent BRL 39123 [9-(4-hydroxy-3-hydroxymethylbut-l-yl)guanine; penciclovir]

R. Anthony Vere Hodge, David Sutton, M R Boyd et al. · Antimicrobial Agents and Chemotherapy · 1989 · 210 citations · Full text

Pharmaceutical Science, Brl 42810, Pharmacotherapy +17

Crystal structure of <i>Staphylococcus aureus</i> tyrosyl‐tRNA synthetase in complex with a class of potent and specific inhibitors

Xiayang Qiu, Cheryl A. Janson, Ward W. Smith et al. · Protein Science · 2001 · 205 citations · Full text

Synthesis and antiviral activity of 9-[4-hydroxy-3-(hydroxymethyl)but-1-yl]purines

Michael R. Harnden, Richard L. Jarvest, Teresa H. Bacon et al. · Journal of Medicinal Chemistry · 1987 · 155 citations

Exploring the active site of herpes simplex virus type-1 thymidine kinase by X-ray crystallography of complexes with aciclovir and other ligands

J.N. Champness, Matthew Bennett, Frank Wien et al. · Proteins Structure Function and Bioinformatics · 1998 · 139 citations

The antimicrobial natural product chuangxinmycin and Some synthetic analogues are potent and selective inhibitors of bacterial tryptophanyl tRNA synthetase

Murray J. B. Brown, Paul S. Carter, Ashley Fenwick et al. · Bioorganic & Medicinal Chemistry Letters · 2002 · 138 citations

Natural Product Synthesis, Antibiotics, Medicine +10