Concepedia

The design, synthesis and structure–activity relationships of novel isoindoline-based histone deacetylase inhibitors

Michael D. Shultz, Jianmei Fan, Christine Chen, Young Shin Cho, Nicole R. Davis, Sheri Bickford, Kristen Buteau, Xueying Cao, Mats Holmqvist, Meier Hsu,

Bioorganic & Medicinal Chemistry Letters · 2011 · 30 citations · 16 references

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Molecular Properties That Influence the Oral Bioavailability of Drug Candidates

Daniel F. Veber, Stephen R. Johnson, Hung‐Yuan Cheng et al. · Journal of Medicinal Chemistry · 2002 · 8.1K citations

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MGCD0103, a novel isotype-selective histone deacetylase inhibitor, has broad spectrum antitumor activity <i>in vitro</i> and <i>in vivo</i>

Marielle Fournel, Claire Bonfils, Yu Hou et al. · Molecular Cancer Therapeutics · 2008 · 336 citations · Full text

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Synthesis and Histone Deacetylase Inhibitory Activity of New Benzamide Derivatives

Tsuneji Suzuki, Tomoyuki Ando, Katsutoshi Tsuchiya et al. · Journal of Medicinal Chemistry · 1999 · 291 citations · Full text

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Phase 1 study of the oral isotype specific histone deacetylase inhibitor MGCD0103 in leukemia

Guillermo Garcia‐Manero, Sarit Assouline, Jörge E. Cortes et al. · Blood · 2008 · 234 citations · Full text

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A Phase I and Pharmacokinetic Study of the Oral Histone Deacetylase Inhibitor, MS-275, in Patients with Refractory Solid Tumors and Lymphomas

Lia Gore, Mace L. Rothenberg, Cindy L. O’Bryant et al. · Clinical Cancer Research · 2008 · 173 citations · Full text

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