Generation of monoclonal antibody that distinguishes PrPSc from PrPC and neutralizes prion infectivity

Conversion of alpha-helices into beta-sheets features in the formation of the scrapie prion proteins.

K M Pan, M. A. Baldwin, Jack Nguyen et al. · Proceedings of the National Academy of Sciences · 1993 · 2.3K citations

Life Sciences, Biochemistry, Molecular Biology +17

A cellular gene encodes scrapie PrP 27-30 protein

Bruno Oesch, David Westaway, Monika Wälchli et al. · Cell · 1985 · 1.5K citations

Veterinary Medicine, Molecular Biology, Molecular Genetics +13

Eight prion strains have PrPSc molecules with different conformations

Jiri Safar, Holger Wille, Vincenza Itri et al. · Nature Medicine · 1998 · 1.2K citations

Life Sciences, Biochemistry, Molecular Biology +14

Apolipoprotein E immunoreactivity in cerebral amyloid deposits and neurofibrillary tangles in Alzheimer's disease and kuru plaque amyloid in Creutzfeldt-Jakob disease

Yoshio Namba, Masanori Tomonaga, Hiroshi Kawasaki et al. · Brain Research · 1991 · 1.2K citations

Life Sciences, Neurology, Neuroscience +16

The most infectious prion protein particles

Jay R. Silveira, Gregory J. Raymond, Andrew G. Hughson et al. · Nature · 2005 · 890 citations · Full text

Veterinary Medicine, Microbiology, Molecular Biology +10