Synthesis and anti-influenza activities of carboxyl alkoxyalkyl esters of 4-guanidino-Neu5Ac2en (zanamivir)

Rational design of potent sialidase-based inhibitors of influenza virus replication

Mark von Itzstein, Wen‐Yang Wu, Gaik B. Kok et al. · Nature · 1993 · 1.9K citations

Pharmacy, Medicinal Chemistry, Molecular Biology +16

Influenza Neuraminidase Inhibitors Possessing a Novel Hydrophobic Interaction in the Enzyme Active Site:  Design, Synthesis, and Structural Analysis of Carbocyclic Sialic Acid Analogues with Potent Anti-Influenza Activity

Choung U. Kim, Willard Lew, Matthew A. Williams et al. · Journal of the American Chemical Society · 1997 · 1.1K citations

Pharmacy, Medicinal Chemistry, Pharmacology +17

4-Guanidino-2,4-dideoxy-2,3-dehydro-N-acetylneuraminic acid is a highly effective inhibitor both of the sialidase (neuraminidase) and of growth of a wide range of influenza A and B viruses in vitro

Jacqueline M. Woods, Richard C. Bethell, Jonathon Alexis Coates et al. · Antimicrobial Agents and Chemotherapy · 1993 · 312 citations

Life Sciences, Microbiology, Pharmacology +12

Structure−Activity Relationship Studies of Novel Carbocyclic Influenza Neuraminidase Inhibitors

Choung U. Kim, Willard Lew, Matthew A. Williams et al. · Journal of Medicinal Chemistry · 1998 · 290 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +15

Oral Administration of a Prodrug of the Influenza Virus Neuraminidase Inhibitor GS 4071 Protects Mice and Ferrets against Influenza Infection

Dirk B. Mendel, Chun Y. Tai, Paul A. Escarpe et al. · Antimicrobial Agents and Chemotherapy · 1998 · 255 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +12