Richard C. Bethell

Rational design of potent sialidase-based inhibitors of influenza virus replication

Mark von Itzstein, Wen‐Yang Wu, Gaik B. Kok et al. · Nature · 1993 · 1.9K citations

Pharmacy, Medicinal Chemistry, Molecular Biology +16

Evidence for Zanamivir Resistance in an Immunocompromised Child Infected with Influenza B Virus

Larisa V. Gubareva, Mikhail Matrosovich, M K Brenner et al. · The Journal of Infectious Diseases · 1998 · 438 citations

Life Sciences, Infectious Diseases, Pharmacotherapy +17

Dihydropyrancarboxamides Related to Zanamivir:  A New Series of Inhibitors of Influenza Virus Sialidases. 1. Discovery, Synthesis, Biological Activity, and Structure−Activity Relationships of 4-Guanidino- and 4-Amino-4<i>H</i>-pyran-6-carboxamides

Paul W. Smith, Steven L. Sollis, Peter D. Howes et al. · Journal of Medicinal Chemistry · 1998 · 343 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

4-Guanidino-2,4-dideoxy-2,3-dehydro-N-acetylneuraminic acid is a highly effective inhibitor both of the sialidase (neuraminidase) and of growth of a wide range of influenza A and B viruses in vitro

Jacqueline M. Woods, Richard C. Bethell, Jonathon Alexis Coates et al. · Antimicrobial Agents and Chemotherapy · 1993 · 312 citations

Life Sciences, Microbiology, Pharmacology +12

Catalytic and framework mutations in the neuraminidase active site of influenza viruses that are resistant to 4-guanidino-Neu5Ac2en

Larisa V. Gubareva, Megan J. Robinson, Richard C. Bethell et al. · Journal of Virology · 1997 · 214 citations · Full text

Life Sciences, Biology, Infectious Diseases +14