Discovery of γ-secretase inhibitors efficacious in a transgenic animal model of Alzheimer’s disease

Early-onset Amyloid Deposition and Cognitive Deficits in Transgenic Mice Expressing a Double Mutant Form of Amyloid Precursor Protein 695

M. Azhar Chishti, Dun-Shen Yang, Christopher Janus et al. · Journal of Biological Chemistry · 2001 · 954 citations · Full text

Life Sciences, Neurobiology, Neuroscience +17

Cassette‐accelerated rapid rat screen: a systematic procedure for the dosing and liquid chromatography/atmospheric pressure ionization tandem mass spectrometric analysis of new chemical entities as part of new drug discovery

Walter A. Korfmacher, Kathleen Cox, Kwokei Ng et al. · Rapid Communications in Mass Spectrometry · 2001 · 151 citations

Pharmacy, Pharmacokinetics, Pharmacology +15

Biochemical Characterization of the γ-Secretase Activity That Produces β-Amyloid Peptides

Lili Zhang, Lixin Song, Giuseppe Terracina et al. · Biochemistry · 2001 · 88 citations

Life Sciences, Biochemistry, Neuroscience +16

Deaths attributable to Alzheimer's disease in the United States.

D. Ewbank · American Journal of Public Health · 1999 · 67 citations · Full text

Social Sciences, Demography, Geriatric Medicine +17

Titanium-Mediated Diastereoselective Formation of (E)- or (Z)-2-Substituted 1-Vinylcyclopropanols: Scope and Limitation, Applications

Sandrine Racouchot, I. Sylvestre, Jean Ollivier et al. · European Journal of Organic Chemistry · 2002 · 48 citations

Natural Sciences, Chemistry, Catalysis +15