Thomas Bara

Chronic Treatment with the γ-Secretase Inhibitor LY-411,575 Inhibits β-Amyloid Peptide Production and Alters Lymphopoiesis and Intestinal Cell Differentiation

Gwendolyn T. Wong, Denise Manfra, Frederique M. Poulet et al. · Journal of Biological Chemistry · 2004 · 715 citations · Full text

Synthesis, SAR, and Biological Evaluation of Oximino-Piperidino-Piperidine Amides. 1. Orally Bioavailable CCR5 Receptor Antagonists with Potent Anti-HIV Activity

Anandan Palani, Sherry Shapiro, Hubert Josien et al. · Journal of Medicinal Chemistry · 2002 · 79 citations · Full text

Combinatorial Chemistry, Bioorganic Chemistry, Oximino-piperidino-piperidine Amides +20

Studies to Investigate the in Vivo Therapeutic Window of the γ-Secretase Inhibitor N2-[(2 S)-2-(3,5-Difluorophenyl)-2-hydroxyethanoyl]-N1-[(7 S)-5-methyl-6-oxo-6,7-dihydro-5 H-dibenzo[b,d]azepin-7-yl]-l-alaninamide (LY411,575) in the CRND8 Mouse

Lynn A. Hyde, Nansie A. McHugh, Joseph Chen et al. · Journal of Pharmacology and Experimental Therapeutics · 2006 · 68 citations

Cyclic Hydroxyamidines as Amide Isosteres: Discovery of Oxadiazolines and Oxadiazines as Potent and Highly Efficacious γ-Secretase Modulators in Vivo

Z. J. Sun, Theodros Asberom, Thomas Bara et al. · Journal of Medicinal Chemistry · 2011 · 52 citations · Full text

2,6-Disubstituted N-arylsulfonyl piperidines as γ-secretase inhibitors

Dmitri Pissarnitski, Theodros Asberom, Thomas Bara et al. · Bioorganic & Medicinal Chemistry Letters · 2006 · 39 citations · Full text

Molecular Pharmacology, Medicinal Chemistry, Biochemistry +8