Reduction of Toxic Metabolite Formation of Acetaminophen

Characterization of rat and human liver microsomal cytochrome P-450 forms involved in nifedipine oxidation, a prototype for genetic polymorphism in oxidative drug metabolism.

F. Peter Guengerich, M V Martin, Philippe Beaune et al. · Journal of Biological Chemistry · 1986 · 730 citations · Full text

Medicine, Biochemistry, Pharmacology +17

Human cytochrome P-450PA (P-450IA2), the phenacetin O-deethylase, is primarily responsible for the hepatic 3-demethylation of caffeine and N-oxidation of carcinogenic arylamines.

Marguerite A. Butler, M. Iwasaki, F. Peter Guengerich et al. · Proceedings of the National Academy of Sciences · 1989 · 638 citations · Full text

Medicine, Pharmacology, Toxicology +17

Hydroxylation of warfarin by human cDNA-expressed cytochrome P-450: a role for P-4502C9 in the etiology of (S)-warfarin-drug interactions

Allan E. Rettie, Kenneth R. Korzekwa, Kent L. Kunze et al. · Chemical Research in Toxicology · 1992 · 602 citations

Medicine, Pharmacology, Toxicology +17

Hydroxylation of chlorzoxazone as a specific probe for human liver cytochrome P-450IIE1

Raimund M. Peter, Ronald Boecker, Philippe Beaune et al. · Chemical Research in Toxicology · 1990 · 535 citations

Medicine, Pharmacology, Toxicology +11

Preparation and Properties of Partially Purified Cytochrome P-450 and Reduced Nicotinamide Adenine Dinucleotide Phosphate-Cytochrome P-450 Reductase from Rabbit Liver Microsomes

Theodore A. van der Hoeven, Minor J. Coon · Journal of Biological Chemistry · 1974 · 519 citations · Full text

Medicine, Biochemistry, Pharmacology +16