Concepedia

Direct activation of protein kinases by unanchored polyubiquitin chains

Zong-Ping Xia, Lijun Sun, Xiang Chen, Gabriel Pineda, Xiaomo Jiang, Anirban Adhikari, Wenwen Zeng, Zhijian J. Chen

Nature · 2009 · 563 citations · 23 references

DOIFull text

Open access

Concepts

References

23

TAK1 is a ubiquitin-dependent kinase of MKK and IKK

Chen Wang, Li Deng, Mei Hong et al. · Nature · 2001 · 2.1K citations

, , +5

Activation of the IκB Kinase Complex by TRAF6 Requires a Dimeric Ubiquitin-Conjugating Enzyme Complex and a Unique Polyubiquitin Chain

Li Deng, Chen Wang, Erika Spencer et al. · Cell · 2000 · 1.9K citations · Full text

, , +16

Activation of IKK by TNFα Requires Site-Specific Ubiquitination of RIP1 and Polyubiquitin Binding by NEMO

Chee-Kwee Ea, Li Deng, Zong-Ping Xia et al. · Molecular Cell · 2006 · 981 citations · Full text

, , +14

Involvement of linear polyubiquitylation of NEMO in NF-κB activation

Fuminori Tokunaga, Shin‐ichi Sakata, Yasushi Saeki et al. · Nature Cell Biology · 2009 · 936 citations

, , +10

TAB2 and TAB3 Activate the NF-κB Pathway through Binding to Polyubiquitin Chains

Atsuhiro Kanayama, Rashu B. Seth, Lijun Sun et al. · Molecular Cell · 2004 · 869 citations · Full text

, , +8