Identification and Characterization of MAVS, a Mitochondrial Antiviral Signaling Protein that Activates NF-κB and IRF3

Rashu B. Seth, Lijun Sun, Chee-Kwee Ea, +1

Cell

Signal TransductionMitochondrial FunctionMitochondrial DynamicViral ImmunityImmunology +4

Activation of IKK by TNFα Requires Site-Specific Ubiquitination of RIP1 and Polyubiquitin Binding by NEMO

Chee-Kwee Ea, Li Deng, Zong-Ping Xia, +2

Molecular Cell

Transcriptional RegulationSignal TransductionSignaling PathwayCell RegulationPolyubiquitin Binding +7

TAB2 and TAB3 Activate the NF-κB Pathway through Binding to Polyubiquitin Chains

Atsuhiro Kanayama, Rashu B. Seth, Lijun Sun, +6

Molecular Cell

InflammationCytokineTranscriptional RegulationSignal TransductionSignaling Pathway +12

The TRAF6 Ubiquitin Ligase and TAK1 Kinase Mediate IKK Activation by BCL10 and MALT1 in T Lymphocytes

Lijun Sun, Li Deng, Chee-Kwee Ea, +2

Molecular Cell

Signal TransductionAutoimmune DiseaseTraf6 Ubiquitin LigaseT-regulatory CellImmunology +7

<i>miR-146a</i> controls the resolution of T cell responses in mice

Lili Yang, Mark Boldin, Yang Yu, +6

The Journal of Experimental Medicine

Regulation of NF-κB activity through lysine monomethylation of p65

Chee-Kwee Ea, David Baltimore

Proceedings of the National Academy of Sciences

Lysine MonomethylationMolecular RegulationEpigenetic ChangeImmunologyTnfalpha Stimulation +14

Inducible RasGEF1B circular RNA is a positive regulator of ICAM-1 in the TLR4/LPS pathway

Wei Lun Ng, Georgi K. Marinov, Ee Shan Liau, +3

RNA Biology

Transcriptional RegulationSystems BiologySignal TransductionFunctional GenomicsCircular Rnas +13

Increase of the resistance of human cervical carcinoma cells to cisplatin by inhibition of the MEK to ERK signaling pathway partly via enhancement of anticancer drug-induced NFκB activation

Pei Yen Yeh, Shuang‐En Chuang, Kun‐Huei Yeh, +3

Biochemical Pharmacology

MedicineReceptor Tyrosine KinaseCell BiologyTumor SuppressorOncology +4

TIFA activates IκB kinase (IKK) by promoting oligomerization and ubiquitination of TRAF6

Chee-Kwee Ea, Lijun Sun, Jun‐ichiro Inoue, +1

Proceedings of the National Academy of Sciences

EHMT1 Protein Binds to Nuclear Factor-κB p50 and Represses Gene Expression

Chee-Kwee Ea, ShengLi Hao, Kok Siong Yeo, +1

Journal of Biological Chemistry

Transcriptional RegulationSignaling PathwayCell RegulationMolecular RegulationEhmt1 Protein Binds +11