Concepedia

Defining dose–response relationships in the therapeutic blockade of B7RP-1-dependent immune responses

Daniela Metz, Deanna Mohn, Ming Zhang, Tom Horan, Helen Kim, Rohini Deshpande, Frederick W. Jacobsen, Wenyan Shen, Liana Zhang, George J. Doellgast,

European Journal of Pharmacology · 2009 · 10 citations · 22 references

DOI

Concepts

References

22

ICOS co-stimulatory receptor is essential for T-cell activation and function

Chen Dong, Amy E. Juedes, Ulla Angela Temann et al. · Nature · 2001 · 942 citations

, , +13

Antigen-specific regulatory T cells develop via the ICOS–ICOS-ligand pathway and inhibit allergen-induced airway hyperreactivity

Omid Akbari, Gordon J. Freeman, Everett Meyer et al. · Nature Medicine · 2002 · 788 citations

, , +16

T-cell co-stimulation through B7RP-1 and ICOS

Steven K. Yoshinaga, John Whoriskey, Sanjay D. Khare et al. · Nature · 1999 · 764 citations

, , +12

Homozygous loss of ICOS is associated with adult-onset common variable immunodeficiency

Bodo Grimbacher, Andreas Hutloff, Michael Schlesier et al. · Nature Immunology · 2003 · 730 citations

, , +14

ICOS is essential for effective T-helper-cell responses

Arda Shahinian, Friedhelm Bladt, Steve K. Yoshinaga et al. · Nature · 2001 · 667 citations

, , +9