T-cell cytokines in chronic allergic eye disease

Daniela Metz, Melanie Hingorani, Virginia L. Calder, +1

Journal of Allergy and Clinical Immunology

Autoimmune DiseaseAllergyT-regulatory CellImmune RegulationImmunology +4

B7RP-1 Blockade Ameliorates Autoimmunity through Regulation of Follicular Helper T Cells

Yiling Hu, Daniela Metz, James Chung, +2

The Journal of Immunology

T-regulatory CellImmune RegulationImmunologyImmunologic MechanismImmunotherapy +15

Phenotypic characterization of T cells infiltrating the conjunctiva in chronic allergic eye disease

Daniela Metz, A S Bacon, Stephen T. Holgate, +1

Journal of Allergy and Clinical Immunology

Discovery and in Vivo Evaluation of (<i>S</i>)-<i>N</i>-(1-(7-Fluoro-2-(pyridin-2-yl)quinolin-3-yl)ethyl)-9<i>H</i>-purin-6-amine (AMG319) and Related PI3Kδ Inhibitors for Inflammation and Autoimmune Disease

Timothy D. Cushing, Xiaolin Hao, Youngsook Shin, +32

Journal of Medicinal Chemistry

Pharmaceutical ScienceImmune RegulationImmunologyPharmacotherapyExcellent Selectivity +21

Characterisation of the Normal Conjunctival Leukocyte Population

Melanie Hingorani, Daniela Metz, Susan Lightman

Experimental Eye Research

Primary ImmunodeficiencyAutoimmune DiseaseGranulocyteImmunodeficienciesHematology +4

Discovery of Aminoquinazolines as Potent, Orally Bioavailable Inhibitors of Lck:  Synthesis, SAR, and in Vivo Anti-Inflammatory Activity

Erin F. DiMauro, John Newcomb, Joseph J. Nunes, +38

Journal of Medicinal Chemistry

Pharmaceutical ScienceImmunologyImmunologic MechanismPharmacotherapyImmunotherapeutics +18

IL-17RA Signaling in Airway Inflammation and Bronchial Hyperreactivity in Allergic Asthma

Cynthia R. Willis, Lori Siegel, Anh Leith, +10

American Journal of Respiratory Cell and Molecular Biology

Differential Role of CTLA-4 in Regulation of Resting Memory Versus Naive CD4 T Cell Activation

Daniela Metz, Donna L. Färber, Terrie E. Taylor, +1

The Journal of Immunology

Memory T CellsSignal TransductionMedicineT-regulatory CellImmunology +13

Novel 2-Aminopyrimidine Carbamates as Potent and Orally Active Inhibitors of Lck:  Synthesis, SAR, and in Vivo Antiinflammatory Activity

Matthew W. Martin, John Newcomb, Joseph J. Nunes, +42

Journal of Medicinal Chemistry

ImmunologyPharmacotherapyImmunotherapyChemical BiologyPharmaceutical Chemistry +16

Discovery and in Vivo Evaluation of Dual PI3Kβ/δ Inhibitors

Felix González-López de Turiso, Youngsook Shin, Matthew F. Brown, +22

Journal of Medicinal Chemistry

Pharmaceutical ScienceDual Pi3kβ/δ InhibitorsPharmaceutical ChemistryTranslational Pharmacologyδ Isoforms +14