ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28

Andreas Hutloff, Anna‐Maria Dittrich, Katja C. Beier, +4

Nature

Signal TransductionAutoimmune DiseaseAdaptive Immune SystemImmunologyImmunologic Mechanism +8

Homozygous loss of ICOS is associated with adult-onset common variable immunodeficiency

Bodo Grimbacher, Andreas Hutloff, Michael Schlesier, +9

Nature Immunology

Primary ImmunodeficiencyAllergyAutoimmune DiseaseImmunodeficienciesImmunology +9

Selective Expression of the Chemokine Receptor XCR1 on Cross-presenting Dendritic Cells Determines Cooperation with CD8+ T Cells

Brigitte G. Dorner, Martin B. Dorner, Xuefei Zhou, +10

Immunity

Cancer ImmunosurveillanceImmunologyImmunologic MechanismChemokine Receptor Xcr1T Cell Immunity +7

Roquin represses autoimmunity by limiting inducible T-cell co-stimulator messenger RNA

Di Yu, Andy Hee‐Meng Tan, Xin Hu, +9

Nature

ImmunogeneticsAllergyAutoimmune DiseaseLaboratory ImmunologyImmunology +7

ICOS maintains the T follicular helper cell phenotype by down-regulating Krüppel-like factor 2

Jan P. Weber, Franziska Fuhrmann, Randi K. Feist, +13

The Journal of Experimental Medicine

InflammationSignal TransductionAutoimmune DiseaseSignaling PathwayLymphocyte Development +12

ICOS Controls the Pool Size of Effector-Memory and Regulatory T Cells

Yvonne Burmeister, Timo Lischke, Anja Christina Dahler, +5

The Journal of Immunology

LAG-3 Inhibitory Receptor Expression Identifies Immunosuppressive Natural Regulatory Plasma Cells

Andreia C. Lino, Van Duc Dang, Vicky Lampropoulou, +27

Immunity

Expression of ICOS In Vivo Defines CD4+ Effector T Cells with High Inflammatory Potential and a Strong Bias for Secretion of Interleukin 10

Max Löhning, Andreas Hutloff, Tilmann Kallinich, +5

The Journal of Experimental Medicine

ICOS-ligand, expressed on human endothelial cells, costimulates Th1 and Th2 cytokine secretion by memory CD4⁺T cells

Saman Khayyamian, Andreas Hutloff, Kerstin Büchner, +4

Proceedings of the National Academy of Sciences

Involvement of inducible costimulator in the exaggerated memory B cell and plasma cell generation in systemic lupus erythematosus

Andreas Hutloff, Kerstin Büchner, Karin Reiter, +5

Arthritis & Rheumatism