ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28

Immunoenzymatic labeling of monoclonal antibodies using immune complexes of alkaline phosphatase and monoclonal anti-alkaline phosphatase (APAAP complexes).

J L Cordell, Brunangelo Falini, Wendy N. Erber et al. · Journal of Histochemistry & Cytochemistry · 1984 · 3.2K citations

Medicine, Biochemistry, Pathology +17

Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4

Elizabeth Tivol, Frank Borriello, Alain Schweitzer et al. · Immunity · 1995 · 2.9K citations · Full text

Life Sciences, Immunology, Pathology +14

CTLA-4 can function as a negative regulator of T cell activation

Theresa L. Walunas, Deborah J. Lenschow, Christina Y. Bakker et al. · Immunity · 1994 · 2.2K citations

Life Sciences, Immunology, Molecular Biology +14

A new member of the immunoglobulin superfamily—CTLA-4

Jean‐François Brunet, François Denizot, Marie‐Françoise Luciani et al. · Nature · 1987 · 1.3K citations

Life Sciences, Immunology, Molecular Biology +11

Differential T Cell Costimulatory Requirements in CD28-Deficient Mice

Arda Shahinian, Klaus Pfeffer, Kelvin P. Lee et al. · Science · 1993 · 1.3K citations

Life Sciences, Cell Biology, Immunology +17