Concepedia

Cd28 Signaling

CD28 Signaling is a molecular activation pathway in T cells that, as a co-stimulatory receptor-ligand interaction, distinguishes itself from primary antigen recognition by providing a secondary signal essential for full T cell activation, proliferation, and survival.

2.3K

Publications

213.2K

Citations

11.3K

Authors

2K

Institutions

Publications per year

2017–2026

315

Parents

Publications

2.3K

CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation.

Matthew F. Krummel, James P. Allison · The Journal of Experimental Medicine · 1995 · 2.2K citations · Full text

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B7/CD28 Costimulation Is Essential for the Homeostasis of the CD4+CD25+ Immunoregulatory T Cells that Control Autoimmune Diabetes

Deborah J. Lenschow, Lesley Rhee, Neda Ashourian et al. · Immunity · 2000 · 2K citations · Full text

, , +16

CD4+CD25high Regulatory Cells in Human Peripheral Blood

Clare Baecher‐Allan, Julia A. Brown, Gordon J. Freeman et al. · The Journal of Immunology · 2001 · 1.8K citations · Full text

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CTLA-4 is a second receptor for the B cell activation antigen B7.

Peter S. Linsley, William Brady, M Urnes et al. · The Journal of Experimental Medicine · 1991 · 1.7K citations · Full text

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T cell costimulatory receptor CD28 is a primary target for PD-1–mediated inhibition

Enfu Hui, Jeanne Cheung, Jing Zhu et al. · Science · 2017 · 1.7K citations · Full text

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Authors

11.3K

  1. CH
    Carl H. June

    University of Pennsylvania, United States

    54 publications · 11.2K citations

    45

    h-index

  2. CB
    Craig B. Thompson

    University of Pennsylvania, United States

    37 publications · 9.8K citations

    32

    h-index

  3. DO
    Daniel Olive

    Inserm, France

    38 publications · 2.4K citations

    29

    h-index

  4. JA
    Jeffrey A. Bluestone

    University of California, San Francisco, United States

    35 publications · 6.1K citations

    28

    h-index

  5. PS
    Peter S. Linsley

    Bristol-Myers Squibb (United States), United States

    32 publications · 8.3K citations

    25

    h-index

1–5 of 11.3K

Institutions

2K

  1. Harvard University

    Cambridge, United States

    58 h-index

    348 publications

    42K citations

  2. Howard Hughes Medical Institute

    Chevy Chase, United States

    54 h-index

    207 publications

    52.6K citations

  3. University of Pennsylvania

    Philadelphia, United States

    47 h-index

    359 publications

    69K citations

  4. Inserm

    Paris, France

    43 h-index

    535 publications

    35.1K citations

  5. Bristol-Myers Squibb (United States)

    New York, United States

    42 h-index

    233 publications

    66.2K citations

  6. Brigham and Women's Hospital

    Boston, United States

    41 h-index

    229 publications

    29.1K citations

  7. National Institutes of Health

    Bethesda, United States

    41 h-index

    263 publications

    28.2K citations

  8. Dana-Farber Cancer Institute

    Boston, United States

    39 h-index

    190 publications

    39.1K citations

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Venues

  1. The Journal of Immunology

    JI · 536 publications · 51.5K citations

    118

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  2. The Journal of Experimental Medicine

    92 publications · 23.1K citations

    71

    h-index

  3. European Journal of Immunology

    EJI · 164 publications · 10.2K citations

    59

    h-index

  4. Proceedings of the National Academy of Sciences

    PNAS · 53 publications · 9.4K citations

    47

    h-index

  5. Blood

    56 publications · 5.7K citations

    42

    h-index

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