T cell costimulatory receptor CD28 is a primary target for PD-1–mediated inhibition

Enfu Hui, Jeanne Cheung, Jing Zhu, +8

Science

Programmed Cell Death-1Adaptive Immune SystemT-regulatory CellImmunologyCell Death +16

Phase separation of signaling molecules promotes T cell receptor signal transduction

Xiaolei Su, Jonathon A. Ditlev, Enfu Hui, +7

Science

T-regulatory CellImmunologyAntigen ProcessingCytoskeletonProtein Phase Separation +18

PD-L1:CD80 Cis-Heterodimer Triggers the Co-stimulatory Receptor CD28 While Repressing the Inhibitory PD-1 and CTLA-4 Pathways

Yunlong Zhao, Calvin K. Lee, Chia‐Hao Lin, +8

Immunity

Signal TransductionCd80 Cis-heterodimer TriggersImmunologyReceptor (Biochemistry)Co-stimulatory Receptor Cd28 +7

Mechanistic convergence of the TIGIT and PD-1 inhibitory pathways necessitates co-blockade to optimize anti-tumor CD8+ T cell responses

Karl L. Banta, Xiaozheng Xu, Avantika S. Chitre, +12

Immunity

Synaptotagmin-Mediated Bending of the Target Membrane Is a Critical Step in Ca2+-Regulated Fusion

Enfu Hui, Colin P. Johnson, Jun Yao, +2

Cell

Membrane FusionTarget MembraneProtein SecretionSynaptotagmin-mediated BendingSignal Transduction +12

Synaptotagmin arrests the SNARE complex before triggering fast, efficient membrane fusion in response to Ca2+

Michael C. Chicka, Enfu Hui, Huisheng Liu, +1

Nature Structural & Molecular Biology

Protein SecretionSignal TransductionEfficient Membrane FusionNatural SciencesMembrane Transport +9

Three distinct kinetic groupings of the synaptotagmin family: Candidate sensors for rapid and delayed exocytosis

Enfu Hui, Jihong Bai, Ping Wang, +3

Proceedings of the National Academy of Sciences

Antigen-Presenting Cell-Intrinsic PD-1 Neutralizes PD-L1 in cis to Attenuate PD-1 Signaling in T Cells

Yunlong Zhao, Devin Harrison, Yuran Song, +3

Cell Reports

Multiple Signaling Roles of CD3ε and Its Application in CAR-T Cell Therapy

Wei Wu, Qiuping Zhou, Takeya Masubuchi, +15

Cell

Signal TransductionT-regulatory CellImmunologyCar-t Cell TherapyImmunologic Mechanism +10

Ca2+ and synaptotagmin VII–dependent delivery of lysosomal membrane to nascent phagosomes

Cecilia Czibener, Nathan M. Sherer, Steven M. Becker, +5

The Journal of Cell Biology

Synaptotagmin Vii–dependent DeliveryImmunologySyt FamilyImmunologic MechanismSynaptic Signaling +20