Concepedia

Discovery and optimization of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists

Daniel J. Buzard, Sun Hee Kim, Juerg Lehmann, Sangdon Han, Imelda Calderon, Amy Wong, Andrew M. Kawasaki, Sanju Narayanan, Rohit Bhat, Tawfik Gharbaoui,

Bioorganic & Medicinal Chemistry Letters · 2014 · 11 citations · 5 references

DOIFull text

Open access

Concepts

References

5

A Role for Intestinal Endocrine Cell-Expressed G Protein-Coupled Receptor 119 in Glycemic Control by Enhancing Glucagon-Like Peptide-1 and Glucose-Dependent Insulinotropic Peptide Release

Zhi‐Liang Chu, Christopher J. Carroll, Jean Alfonso et al. · Endocrinology · 2008 · 380 citations

, , +17

A Role for β-Cell-Expressed G Protein-Coupled Receptor 119 in Glycemic Control by Enhancing Glucose-Dependent Insulin Release

Zhi‐Liang Chu, Robert M. Jones, Hongmei He et al. · Endocrinology · 2007 · 292 citations

, , +17

Discovery of the First Potent and Orally Efficacious Agonist of the Orphan G-Protein Coupled Receptor 119

Graeme Semple, Beatriz Fioravanti, Imelda Calderon et al. · Journal of Medicinal Chemistry · 2008 · 142 citations · Full text

, , +16

N-Oleoyldopamine Enhances Glucose Homeostasis through the Activation of GPR119

Zhi‐Liang Chu, Christopher J. Carroll, Ruoping Chen et al. · Molecular Endocrinology · 2009 · 125 citations · Full text

, , +17

Discovery of a second generation agonist of the orphan G-protein coupled receptor GPR119 with an improved profile

Graeme Semple, Juerg Lehmann, Amy Wong et al. · Bioorganic & Medicinal Chemistry Letters · 2011 · 52 citations · Full text

, , +14