Tawfik Gharbaoui

3-(1<i>H</i>-Tetrazol-5-yl)-1,4,5,6-tetrahydro-cyclopentapyrazole (MK-0354): A Partial Agonist of the Nicotinic Acid Receptor, G-Protein Coupled Receptor 109a, with Antilipolytic but No Vasodilatory Activity in Mice

Graeme Semple, Philip J. Skinner, Tawfik Gharbaoui et al. · Journal of Medicinal Chemistry · 2008 · 93 citations · Full text

No Vasodilatory Activity, Hyperlipidemia, Pharmacotherapy +21

Discovery of APD334: Design of a Clinical Stage Functional Antagonist of the Sphingosine-1-phosphate-1 Receptor

Daniel J. Buzard, Sun Hee Kim, Luis Lopez et al. · ACS Medicinal Chemistry Letters · 2014 · 70 citations · Full text

Immunology, Potent Functional Antagonist, Inflammation +20

Discovery of fused bicyclic agonists of the orphan G-protein coupled receptor GPR119 with in vivo activity in rodent models of glucose control

Graeme Semple, Albert Ren, Beatriz Fioravanti et al. · Bioorganic & Medicinal Chemistry Letters · 2011 · 66 citations · Full text

Signal Transduction, Molecular Physiology, Biochemistry +12

Analogues of Acifran:  Agonists of the High and Low Affinity Niacin Receptors, GPR109a and GPR109b

Jae‐Kyu Jung, Benjamin Johnson, Tracy Duong et al. · Journal of Medicinal Chemistry · 2007 · 54 citations · Full text

Pharmacotherapy, Few Analogs, Drug Resistance +17

Discovery of Selective Phosphodiesterase 1 Inhibitors with Memory Enhancing Properties

Brian Dyck, Bryan J. Branstetter, Tawfik Gharbaoui et al. · Journal of Medicinal Chemistry · 2017 · 54 citations · Full text