Concepedia

Hit-to-probe Optimization

Hit-to-Probe Optimization is a medicinal chemistry-driven process that systematically refines initial screening hits into chemically validated small molecules with enhanced potency, selectivity, and pharmacokinetic properties to enable precise modulation and interrogation of biological targets in complex systems.

62

Publications

2.4K

Citations

728

Authors

144

Institutions

Publications per year

2017–2026

18

Parents

Publications

62

Identification of a chemical probe for NAADP by virtual screening

Edmund Naylor, Abdelilah Arredouani, Sridhar R. Vasudevan et al. · Nature Chemical Biology · 2009 · 299 citations · Full text

, , +13

S1P1-Selective In Vivo-Active Agonists from High- Throughput Screening: Off-the-Shelf Chemical Probes of Receptor Interactions, Signaling, and Fate

Euijung Jo, Marta Sanna, Pedro J. Gonzalez‐Cabrera et al. · Chemistry & Biology · 2005 · 242 citations · Full text

, , +16

Flavanones That Selectively Inhibit TRPM3 Attenuate Thermal Nociception In Vivo

Isabelle Straub, Ute Krügel, Florian Mohr et al. · Molecular Pharmacology · 2013 · 148 citations

, , +17

Open access chemical and clinical probes to support drug discovery

A.M. Edwards, C. Bountra, Timothy M. Willson · Nature Chemical Biology · 2009 · 132 citations

, , +14

Development, interpretation and temporal evaluation of a global QSAR of hERG electrophysiology screening data

Claire L. Gavaghan, Catrin Hasselgren Arnby, Niklas Blomberg et al. · Journal of Computer-Aided Molecular Design · 2007 · 101 citations

, , +14

1–5 of 62

Authors

728

  1. UG
    Uwe Grether

    Roche (Switzerland), Switzerland

    2 publications · 32 citations

    2

    h-index

  2. HL
    Hai‐Bin Luo

    Sun Yat-sen University, China

    2 publications · 74 citations

    2

    h-index

  3. GM
    György M. Keserű

    HUN-REN Research Centre for Natural Sciences, Hungary

    2 publications · 51 citations

    2

    h-index

  4. QZ
    Qian Zhou

    Sun Yat-sen University, China

    2 publications · 74 citations

    2

    h-index

  5. LD
    Lewis D. Pennington

    Amgen (United States), United States

    2 publications · 67 citations

    2

    h-index

1–5 of 728

Institutions

144

  1. Harvard University

    Cambridge, United States

    5 h-index

    16 publications

    401 citations

  2. Merck & Co., Inc., Rahway, NJ, USA (United States)

    Rahway, United States

    3 h-index

    41 publications

    1.1K citations

  3. University of Toronto

    Toronto, Canada

    3 h-index

    28 publications

    1.7K citations

  4. Sun Yat-sen University

    Guangzhou, China

    3 h-index

    26 publications

    837 citations

  5. Torrey Pines Institute For Molecular Studies

    San Diego, United States

    3 h-index

    31 publications

    760 citations

  6. GlaxoSmithKline (United States)

    Philadelphia, United States

    2 h-index

    10 publications

    402 citations

  7. Boehringer Ingelheim (Germany)

    Ingelheim, Germany

    2 h-index

    10 publications

    286 citations

  8. Italian Institute of Technology

    Genoa, Italy

    2 h-index

    7 publications

    280 citations

1–8 of 144

Venues

  1. Journal of Medicinal Chemistry

    13 publications · 496 citations

    13

    h-index

  2. Bioorganic & Medicinal Chemistry Letters

    15 publications · 325 citations

    12

    h-index

  3. ACS Medicinal Chemistry Letters

    5 publications · 135 citations

    5

    h-index

  4. European Journal of Medicinal Chemistry

    3 publications · 67 citations

    3

    h-index

  5. Chemistry & Biology

    2 publications · 289 citations

    2

    h-index

1–5