Concepedia

Amide-based inhibitors of p38α MAP kinase. Part 1: Discovery of novel N-pyridyl amide lead molecules

Gregory R. Luedtke, Kurt Schinzel, Xuefei Tan, Richland Tester, Imad Nashashibi, Yongjin Xu, Sundeep Dugar, Daniel E. Levy, Joon Jung

Bioorganic & Medicinal Chemistry Letters · 2010 · 10 citations · 13 references

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A protein kinase involved in the regulation of inflammatory cytokine biosynthesis

John C. Lee, Jeffrey T. Laydon, Peter McDonnell et al. · Nature · 1994 · 3.3K citations

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Pharmacological profile of SB 203580, a selective inhibitor of cytokine suppressive binding protein/p38 kinase, in animal models of arthritis, bone resorption, endotoxin shock and immune function.

A M Badger, Jeremy N. Bradbeer, Bartholomew J. Votta et al. · Journal of Pharmacology and Experimental Therapeutics · 1996 · 499 citations

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Structural basis of inhibitor selectivity in MAP kinases

Zhulun Wang, Bertram Canagarajah, Jeffrey C. Boehm et al. · Structure · 1998 · 425 citations · Full text

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Binding Mode of the 4-Anilinoquinazoline Class of Protein Kinase Inhibitor:  X-ray Crystallographic Studies of 4-Anilinoquinazolines Bound to Cyclin-Dependent Kinase 2 and p38 Kinase

Lisa M. Shewchuk, Anne M. Hassell, Bruce Wisely et al. · Journal of Medicinal Chemistry · 1999 · 236 citations · Full text

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Design and Synthesis of Potent, Selective, and Orally Bioavailable Tetrasubstituted Imidazole Inhibitors of p38 Mitogen-Activated Protein Kinase

Nigel J. Liverton, John W. Butcher, Christopher F. Claiborne et al. · Journal of Medicinal Chemistry · 1999 · 196 citations · Full text

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