Lisa M. Shewchuk

A Unique Structure for Epidermal Growth Factor Receptor Bound to GW572016 (Lapatinib)

Edgar R. Wood, Anne T. Truesdale, Octerloney B. McDonald et al. · Cancer Research · 2004 · 1.1K citations · Full text

Crystal Structure, Molecular Biology, Cell Growth +20

Discovery of 7-Methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro-1<i>H</i>-indol-5-yl)-7<i>H</i>-pyrrolo[2,3-<i>d</i>]pyrimidin-4-amine (GSK2606414), a Potent and Selective First-in-Class Inhibitor of Protein Kinase R (PKR)-like Endoplasmic Reticulum Kinase (PERK)

Jeffrey M. Axten, Jesús R. Medina, Yanhong Feng et al. · Journal of Medicinal Chemistry · 2012 · 601 citations · Full text

Chemoprevention Strategy, Chemical Biology, Pharmaceutical Chemistry +24

Escherichia coli biotin holoenzyme synthetase/bio repressor crystal structure delineates the biotin- and DNA-binding domains.

Keith P. Wilson, Lisa M. Shewchuk, Richard G. Brennan et al. · Proceedings of the National Academy of Sciences · 1992 · 294 citations · Full text

Biosynthesis, Biochemistry, Protein Assembly +13

Oxindole-Based Inhibitors of Cyclin-Dependent Kinase 2 (CDK2):  Design, Synthesis, Enzymatic Activities, and X-ray Crystallographic Analysis

H. Neal Bramson, J. Corona, Stephen T. Davis et al. · Journal of Medicinal Chemistry · 2001 · 267 citations · Full text

Oxindole-based Inhibitors, Oxindole-based Compounds, Ligand Docking +16

The Drosophila Orphan Nuclear Receptor DHR38 Mediates an Atypical Ecdysteroid Signaling Pathway

K.D. Baker, Lisa M. Shewchuk, Tatiana Kozlova et al. · Cell · 2003 · 236 citations · Full text

Developmental Biology, Developmental Genetics, Genetics +4