Concepedia

Finding the perfect spot for fluorine: Improving potency up to 40-fold during a rational fluorine scan of a Bruton’s Tyrosine Kinase (BTK) inhibitor scaffold

Yan Lou, Zachary K. Sweeney, A. Kuglstatter, Dana Davis, David Goldstein, Xiaochun Han, Jun‐Bae Hong, Buelent Koçer, Rama K. Kondru, Renée Litman,

Bioorganic & Medicinal Chemistry Letters · 2014 · 33 citations · 13 references

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13

The Many Roles for Fluorine in Medicinal Chemistry

William K. Hagmann · Journal of Medicinal Chemistry · 2008 · 3.6K citations · Full text

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Synopsis of Some Recent Tactical Application of Bioisosteres in Drug Design

Nicholas A. Meanwell · Journal of Medicinal Chemistry · 2011 · 2.8K citations · Full text

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On the attribution and additivity of binding energies

William P. Jencks · Proceedings of the National Academy of Sciences · 1981 · 921 citations · Full text

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(2<i>R</i>)-4-Oxo-4-[3-(Trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-<i>a</i>]pyrazin- 7(8<i>H</i>)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine:  A Potent, Orally Active Dipeptidyl Peptidase IV Inhibitor for the Treatment of Type 2 Diabetes

Dooseop Kim, Liping Wang, Maria Beconi et al. · Journal of Medicinal Chemistry · 2004 · 817 citations · Full text

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A Fluoride-Derived Electrophilic Late-Stage Fluorination Reagent for PET Imaging

Eunsung Lee, Adam S. Kamlet, David C. Powers et al. · Science · 2011 · 413 citations · Full text

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