Renée Litman

Structure-Based Drug Design of RN486, a Potent and Selective Bruton’s Tyrosine Kinase (BTK) Inhibitor, for the Treatment of Rheumatoid Arthritis

Yan Lou, Xiaochun Han, A. Kuglstatter et al. · Journal of Medicinal Chemistry · 2014 · 108 citations

Pharmacy, Medicinal Chemistry, Pharmacology +16

The relationship between physicochemical properties, In vitro activity and pharmacokinetic profiles of analogues of diamine-Containing efflux pump inhibitors

William J. Watkins, Yakira Landaverry, Roger Léger et al. · Bioorganic & Medicinal Chemistry Letters · 2003 · 79 citations

Pharmacy, Pharmacokinetics, Pharmacology +17

Discovery of 6-(2,4-Difluorophenoxy)-2-[3-hydroxy-1-(2-hydroxyethyl)propylamino]-8-methyl-8<i>H</i>-pyrido[2,3-<i>d</i>]pyrimidin-7-one (Pamapimod) and 6-(2,4-Difluorophenoxy)-8-methyl-2-(tetrahydro-2<i>H</i>-pyran-4-ylamino)pyrido[2,3-<i>d</i>]pyrimidin-7(8<i>H</i>)-one (R1487) as Orally Bioavailable and Highly Selective Inhibitors of p38α Mitogen-Activated Protein Kinase

David Goldstein, Michael Soth, Tobias Gabriel et al. · Journal of Medicinal Chemistry · 2011 · 74 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +11

Finding the perfect spot for fluorine: Improving potency up to 40-fold during a rational fluorine scan of a Bruton’s Tyrosine Kinase (BTK) inhibitor scaffold

Yan Lou, Zachary K. Sweeney, A. Kuglstatter et al. · Bioorganic & Medicinal Chemistry Letters · 2014 · 33 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +13