Identification and Characterization of Inhibitors of Multidrug Resistance Efflux Pumps in <i>Pseudomonas aeruginosa</i> : Novel Agents for Combination Therapy

Olga Lomovskaya, Mark S. Warren, Angela Lee, +13

Antimicrobial Agents and Chemotherapy

Inhibitors of Efflux Pumps in <i>Pseudomonas </i><i>a</i><i>eruginosa</i> Potentiate the Activity of the Fluoroquinolone Antibacterial Levofloxacin

Thomas E. Renau, Roger Léger, Eric M. Flamme, +11

Journal of Medicinal Chemistry

Mountain ViewAltmetric Attention ScoreAntimicrobial ChemotherapyAntibiotic ResistanceDrug Resistance +20

Conformationally-restricted analogues of efflux pump inhibitors that potentiate the activity of levofloxacin in Pseudomonas aeruginosa

Thomas E. Renau, Roger Léger, L. K. FILONOVA, +13

Bioorganic & Medicinal Chemistry Letters

Efflux Pump InhibitorsAntimicrobial SusceptibilityAntibioticsMedicinePseudomonas Aeruginosa +9

MexAB-OprM-Specific efflux pump inhibitors in Pseudomonas aeruginosa. Part 1: Discovery and early strategies for lead optimization

Kiyoshi Nakayama, Yohei Ishida, Masami Ohtsuka, +13

Bioorganic & Medicinal Chemistry Letters

Early StrategiesAntimicrobial SusceptibilityHealth SciencesAntibioticsLead Identification +11

Peptidomimetics of Efflux Pump Inhibitors Potentiate the Activity of Levofloxacin in Pseudomonas aeruginosa

Thomas E. Renau, Roger Léger, Rose Yen, +7

Bioorganic & Medicinal Chemistry Letters

Antimicrobial SusceptibilityHealth SciencesAntibioticsMedicineCombination Therapy +10

The relationship between physicochemical properties, In vitro activity and pharmacokinetic profiles of analogues of diamine-Containing efflux pump inhibitors

William J. Watkins, Yakira Landaverry, Roger Léger, +11

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryPharmaceutical ScienceBiochemistryMedicineNatural Sciences +7

Expedient assembly of carbocyclic, heterocyclic, and polycyclic compounds by trimethylstannyl radical mediated carbocyclizations of dienes and trienes: a novel oxidative cleavage of the carbon-tin bond

Stephen Hanessian, Roger Léger

Journal of the American Chemical Society

Expedient AssemblyCross-coupling ReactionEngineeringHeterocyclicAlkene Metathesis +11

Identification of CJC-1131-albumin bioconjugate as a stable and bioactive GLP-1(7–36) analog

Roger Léger, Karen Thibaudeau, Martin Robitaille, +6

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryBiochemistryNatural SciencesMedicineGlycobiology +8

Addressing the stability of C-capped dipeptide efflux pump inhibitors that potentiate the activity of levofloxacin in Pseudomonas aeruginosa

Thomas E. Renau, Roger Léger, Eric M. Flamme, +9

Bioorganic & Medicinal Chemistry Letters

Antimicrobial SusceptibilityHealth SciencesMedicineCombination TherapyPseudomonas Aeruginosa +9

Stereochemical Elucidation and Total Synthesis of Dihydropacidamycin D, a Semisynthetic Pacidamycin

Constantine G. Boojamra, Rémy C. Lemoine, Julie C. Lee, +10

Journal of the American Chemical Society

Bioorganic ChemistryBiochemistryDihydropacidamycin DNatural SciencesPacidamycin D +9