Total synthesis of antibiotic hygromycin A

Noritaka Chida, Masami Ohtsuka, Keiichi Nakazawa, +1

The Journal of Organic Chemistry

Altmetric Attention ScoreAntimicrobial ChemotherapyMedicinal ChemistryAntimicrobial StewardshipAntimicrobial Resistance +14

Total synthesis of (+)-lycoricidine and its 2-epimer from D-glucose

Noritaka Chida, Masami Ohtsuka, Seiichiro Ogawa

The Journal of Organic Chemistry

Medicinal ChemistryBioorganic ChemistryBiochemistryDonut IconNatural Sciences +9

MexAB-OprM-Specific efflux pump inhibitors in Pseudomonas aeruginosa. Part 1: Discovery and early strategies for lead optimization

Kiyoshi Nakayama, Yohei Ishida, Masami Ohtsuka, +13

Bioorganic & Medicinal Chemistry Letters

Early StrategiesAntimicrobial SusceptibilityHealth SciencesAntibioticsLead Identification +11

Stereoselective total synthesis of (+)-lycoricidine

Noritaka Chida, Masami Ohtsuka, Seiichiro Ogawa

Tetrahedron Letters

Stereoselective Total SynthesisOrganic ChemistryStereoselective SynthesisPharmacologyEnantioselective Synthesis +1

Synthesis of Optically Active Substituted Cyclohexenones from Carbohydrates by Catalytic Ferrier Rearrangement

Noritaka Chida, Masami Ohtsuka, Katsuyuki Ogura, +1

Bulletin of the Chemical Society of Japan

Room TemperatureChemical EngineeringEnantioselective SynthesisEngineeringAlkene Metathesis +9

MexAB-OprM specific efflux pump inhibitors in Pseudomonas aeruginosa. Part 3: Optimization of potency in the pyridopyrimidine series through the application of a pharmacophore model

Kiyoshi Nakayama, Haruko C. Kawato, Jun Watanabe, +14

Bioorganic & Medicinal Chemistry Letters

Pyridopyrimidine SeriesAntimicrobial SusceptibilityMedicinePseudomonas AeruginosaAntibacterial Agent +7

MexAB-OprM specific efflux pump inhibitors in Pseudomonas aeruginosa. Part 6: Exploration of aromatic substituents

Ken‐ichi Yoshida, Kiyoshi Nakayama, Yoshihiro Yokomizo, +9

Bioorganic & Medicinal Chemistry

Antimicrobial SusceptibilityHealth SciencesAntibioticsMedicinePseudomonas Aeruginosa +9

MexAB-OprM specific efflux pump inhibitors in Pseudomonas aeruginosa. Part 2: achieving activity in vivo through the use of alternative scaffolds

Kiyoshi Nakayama, Yohei Ishida, Masami Ohtsuka, +12

Bioorganic & Medicinal Chemistry Letters

Antimicrobial SusceptibilityHealth SciencesAntibioticsMedicineAchieving Activity +10

Total Synthesis of (+)-7-Deoxypancratistatin and (+)-7-Deoxy-trans-dihydronarciclasine

Noritaka Chida, Makoto Jitsuoka, Yoshiyuki Yamamoto, +2

Heterocycles

Phenanthridone AlkaloidsMedicinal ChemistryBioorganic ChemistryBiochemistryNatural Sciences +10

MexAB-OprM specific efflux pump inhibitors in Pseudomonas aeruginosa. Part 4: Addressing the problem of poor stability due to photoisomerization of an acrylic acid moiety

Kiyoshi Nakayama, Noriko Kuru, Masami Ohtsuka, +14

Bioorganic & Medicinal Chemistry Letters

Acrylic Acid MoietyAntimicrobial SusceptibilityAntibioticsPseudomonas AeruginosaAntimicrobial Chemotherapy +7