MexAB-OprM specific efflux pump inhibitors in Pseudomonas aeruginosa. Part 7: Highly soluble and in vivo active quaternary ammonium analogue D13-9001, a potential preclinical candidate

Identification and Characterization of Inhibitors of Multidrug Resistance Efflux Pumps in <i>Pseudomonas aeruginosa</i> : Novel Agents for Combination Therapy

Olga Lomovskaya, Mark S. Warren, Angela Lee et al. · Antimicrobial Agents and Chemotherapy · 2001 · 889 citations · Full text

Life Sciences, Infectious Diseases, Pharmacology +17

Multiple antibiotic resistance in Pseudomonas aeruginosa: evidence for involvement of an efflux operon

Keith Poole, K A Krebes, Ciarán McNally et al. · Journal of Bacteriology · 1993 · 684 citations · Full text

Life Sciences, Microbiology, Molecular Genetics +16

Use of a Genetic Approach To Evaluate the Consequences of Inhibition of Efflux Pumps in <i>Pseudomonas aeruginosa</i>

Olga Lomovskaya, Angela Lee, Kazuki Hoshino et al. · Antimicrobial Agents and Chemotherapy · 1999 · 218 citations · Full text

Life Sciences, Microbiology, Pharmacology +17

MexAB-OprM-Specific efflux pump inhibitors in Pseudomonas aeruginosa. Part 1: Discovery and early strategies for lead optimization

Kiyoshi Nakayama, Yohei Ishida, Masami Ohtsuka et al. · Bioorganic & Medicinal Chemistry Letters · 2003 · 82 citations

Pharmacy, Microbiology, Pharmacology +17

MexAB-OprM specific efflux pump inhibitors in Pseudomonas aeruginosa. Part 3: Optimization of potency in the pyridopyrimidine series through the application of a pharmacophore model

Kiyoshi Nakayama, Haruko C. Kawato, Jun Watanabe et al. · Bioorganic & Medicinal Chemistry Letters · 2003 · 65 citations

Pharmacy, Medicinal Chemistry, Pharmacology +14