Concepedia

Fluorine Scanning

Fluorine Scanning is a systematic medicinal chemistry strategy in which fluorine atoms are selectively introduced at various positions of a lead compound to evaluate the impact on pharmacokinetic, pharmacodynamic, and physicochemical properties, thereby optimizing molecular efficacy and stability.

28

Publications

1.4K

Citations

173

Authors

52

Institutions

Publications per year

2017–2026

4

Parents

Publications

28

A Fluorine Scan of Thrombin Inhibitors to Map the Fluorophilicity/Fluorophobicity of an Enzyme Active Site: Evidence for CF⋅⋅⋅CO Interactions

Jacob Olsen, David W. Banner, Paul Seiler et al. · Angewandte Chemie International Edition · 2003 · 199 citations

, , +17

Fluorine Interactions at the Thrombin Active Site: Protein Backbone Fragments HC<sub>α</sub>CO Comprise a Favorable CF Environment and Interactions of CF with Electrophiles

Jacob Olsen, David W. Banner, Paul Seiler et al. · ChemBioChem · 2004 · 148 citations

, , +17

β-Secretase (BACE1) Inhibitors with High in Vivo Efficacy Suitable for Clinical Evaluation in Alzheimer’s Disease

Hans Hilpert, Wolfgang Guba, Thomas J. Woltering et al. · Journal of Medicinal Chemistry · 2013 · 137 citations · Full text

, , +17

A Ligand That Is Predicted to Bind Better to Avidin than Biotin:  Insights from Computational Fluorine Scanning

Bernd Kuhn, Peter A. Kollman · Journal of the American Chemical Society · 2000 · 112 citations

, , +17

Structure-Based Drug Design: Exploring the Proper Filling of Apolar Pockets at Enzyme Active Sites

Martina Zürcher, François Diederich · The Journal of Organic Chemistry · 2008 · 103 citations

, , +17

1–5 of 28

Authors

173

  1. FD
    François Diederich

    ETH Zurich, Switzerland

    8 publications · 733 citations

    8

    h-index

  2. DW
    David W. Banner

    Roche (Switzerland), Switzerland

    6 publications · 686 citations

    6

    h-index

  3. PS
    Paul Seiler

    ETH Zurich, Switzerland

    6 publications · 607 citations

    6

    h-index

  4. JO
    Jacob Olsen

    ETH Zurich, Switzerland

    5 publications · 579 citations

    5

    h-index

  5. BW
    Björn Wagner

    Roche (Switzerland), Switzerland

    5 publications · 352 citations

    5

    h-index

1–5 of 173

Institutions

52

  1. Roche (Switzerland)

    Basel, Switzerland

    9 h-index

    58 publications

    6.4K citations

  2. ETH Zurich

    Zurich, Switzerland

    8 h-index

    26 publications

    2.3K citations

  3. Foundation Wakasa Wan Energy Research Center

    Tsuruga, Japan

    3 h-index

    3 publications

    45 citations

  4. The University of Osaka

    Osaka, Japan

    3 h-index

    10 publications

    140 citations

  5. Johannes Gutenberg University Mainz

    Mainz, Germany

    2 h-index

    2 publications

    86 citations

  6. Advanced Science Research Center

    Naka, Japan

    2 h-index

    3 publications

    40 citations

  7. Institut Galien Paris-Saclay

    Châtenay-Malabry, France

    1 h-index

    7 publications

    245 citations

  8. University of Surrey

    Guildford, United Kingdom

    1 h-index

    2 publications

    46 citations

1–8 of 52

Venues

  1. ChemMedChem

    3 publications · 135 citations

    3

    h-index

  2. 3

    h-index

  3. American Mineralogist

    2 publications · 46 citations

    2

    h-index

  4. European Journal of Medicinal Chemistry

    2 publications · 49 citations

    2

    h-index

  5. ChemBioChem

    1 publications · 148 citations

    1

    h-index

1–5