Concepedia

Trifluoromethylpyrimidine-based inhibitors of proline-rich tyrosine kinase 2 (PYK2): Structure–activity relationships and strategies for the elimination of reactive metabolite formation

Daniel P. Walker, F. Christopher Bi, Amit S. Kalgutkar, Jonathan Bauman, Sabrina X. Zhao, John R. Soglia, Gary E. Aspnes, Daniel W. Kung, Jacquelyn Klug‐McLeod, Michael P. Zawistoski,

Bioorganic & Medicinal Chemistry Letters · 2008 · 53 citations · 9 references

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9

Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes

R. Scott Obach · Drug Metabolism and Disposition · 1999 · 1.2K citations

, , +17

N-acetyl-p-benzoquinone imine: a cytochrome P-450-mediated oxidation product of acetaminophen.

David C. Dahlin, Gerald T. Miwa, Albert Lu et al. · Proceedings of the National Academy of Sciences · 1984 · 1.1K citations

, , +16

Absence of marginal zone B cells in Pyk-2–deficient mice defines their role in the humoral response

Rodolphe Guinamard, Mitsuhiko Okigaki, Joseph Schlessinger et al. · Nature Immunology · 2000 · 526 citations

, , +14

Cellular Characterization of a Novel Focal Adhesion Kinase Inhibitor

Jill K. Slack‐Davis, Karen H. Martin, Robert W. Tilghman et al. · Journal of Biological Chemistry · 2007 · 483 citations · Full text

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Pyk2 regulates multiple signaling events crucial for macrophage morphology and migration

Mitsuhiko Okigaki, Caitlin M. Davis, Marco Falasca et al. · Proceedings of the National Academy of Sciences · 2003 · 295 citations · Full text

, , +17