Sabrina X. Zhao

Can In Vitro Metabolism-Dependent Covalent Binding Data in Liver Microsomes Distinguish Hepatotoxic from Nonhepatotoxic Drugs? An Analysis of 18 Drugs with Consideration of Intrinsic Clearance and Daily Dose

R. Scott Obach, Amit S. Kalgutkar, John R. Soglia et al. · Chemical Research in Toxicology · 2008 · 213 citations

Pharmacy, Pharmacology, Toxicology +17

Discovery of<i>N</i>-[(3<i>R</i>)-1-Azabicyclo[2.2.2]oct-3-yl]furo[2,3-<i>c</i>]pyridine-5-carboxamide, an Agonist of the α7 Nicotinic Acetylcholine Receptor, for the Potential Treatment of Cognitive Deficits in Schizophrenia:  Synthesis and Structure−Activity Relationship

Donn G. Wishka, Daniel P. Walker, Karen M. Yates et al. · Journal of Medicinal Chemistry · 2006 · 190 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +16

BIOACTIVATION OF THE NONTRICYCLIC ANTIDEPRESSANT NEFAZODONE TO A REACTIVE QUINONE-IMINE SPECIES IN HUMAN LIVER MICROSOMES AND RECOMBINANT CYTOCHROME P450 3A4

Amit S. Kalgutkar, Alfin D. N. Vaz, Mary E. Lame et al. · Drug Metabolism and Disposition · 2004 · 154 citations

Medicine, Medicinal Chemistry, Pharmacology +16

Can In Vitro Metabolism-Dependent Covalent Binding Data Distinguish Hepatotoxic from Nonhepatotoxic Drugs? An Analysis Using Human Hepatocytes and Liver S-9 Fraction

Jonathon N. Bauman, Joan M. Kelly, Sakambari Tripathy et al. · Chemical Research in Toxicology · 2009 · 134 citations

Pharmacy, Pharmacology, Toxicology +16

The development of a higher throughput reactive intermediate screening assay incorporating micro-bore liquid chromatography–micro-electrospray ionization–tandem mass spectrometry and glutathione ethyl ester as an in vitro conjugating agent

John R. Soglia, Shawn Harriman, Sabrina X. Zhao et al. · Journal of Pharmaceutical and Biomedical Analysis · 2004 · 109 citations

Pharmacy, Toxicology, Analytical Chemistry +13