Gary E. Aspnes

Discovery of (<i>S</i>)-6-(3-Cyclopentyl-2-(4-(trifluoromethyl)-1<i>H</i>-imidazol-1-yl)propanamido)nicotinic Acid as a Hepatoselective Glucokinase Activator Clinical Candidate for Treating Type 2 Diabetes Mellitus

Jeffrey A. Pfefferkorn, Angel Guzmán-Pérez, John Litchfield et al. · Journal of Medicinal Chemistry · 2011 · 114 citations · Full text

Structural Characterization of Proline-rich Tyrosine Kinase 2 (PYK2) Reveals a Unique (DFG-out) Conformation and Enables Inhibitor Design

Seungil Han, Anil Mistry, Jeanne S. Chang et al. · Journal of Biological Chemistry · 2009 · 107 citations · Full text

Regioselective Synthesis of 2<i>H</i>-Indazoles Using a Mild, One-Pot Condensation–Cadogan Reductive Cyclization

Nathan E. Genung, Liuqing Wei, Gary E. Aspnes · Organic Letters · 2014 · 105 citations

Natural Sciences, Diversity-oriented Synthesis, Ortho-imino-nitrobenzene Substrates +9

A potentiator of orthosteric ligand activity at GLP-1R acts via covalent modification

Whitney M. Nolte, Jean‐Philippe Fortin, Benjamin D. Stevens et al. · Nature Chemical Biology · 2014 · 85 citations

Molecular Pharmacology, Biochemistry, Functional Selectivity +9

Discovery and Optimization of Imidazopyridine-Based Inhibitors of Diacylglycerol Acyltransferase 2 (DGAT2)

Kentaro Futatsugi, Daniel W. Kung, Suvi T. M. Orr et al. · Journal of Medicinal Chemistry · 2015 · 80 citations

Combinatorial Chemistry, Lipid Analysis, Medicinal Chemistry +14