Histone deacetylase inhibition activates transcription factor Nrf2 and protects against cerebral ischemic damage

The antioxidant responsive element. Activation by oxidative stress and identification of the DNA consensus sequence required for functional activity

Thomas H. Rushmore, Marcia R. Morton, C.B. Pickett · Journal of Biological Chemistry · 1991 · 1.5K citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

Deacetylase inhibition promotes the generation and function of regulatory T cells

Ran Tao, Edwin F. de Zoeten, Engin Özkaynak et al. · Nature Medicine · 2007 · 906 citations

Life Sciences, Immunology, Molecular Biology +14

Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation

Nobunao Wakabayashi, Ken Itoh, Junko Wakabayashi et al. · Nature Genetics · 2003 · 888 citations

Life Sciences, Genetics, Molecular Biology +11

Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor, ameliorates motor deficits in a mouse model of Huntington's disease

Emma Hockly, Victoria M. Richon, Benjamin Woodman et al. · Proceedings of the National Academy of Sciences · 2003 · 841 citations · Full text

Life Sciences, Neuroscience, Pharmacology +17

NRF2, a member of the NFE2 family of transcription factors, is not essential for murine erythropoiesis, growth, and development

Ronghua Lu, Judy C. Chang, Yuet Wai Kan · Proceedings of the National Academy of Sciences · 1996 · 650 citations · Full text

Life Sciences, Genetics, Molecular Biology +12