Cariprazine (RGH-188), a potent D3/D2 dopamine receptor partial agonist, binds to dopamine D3 receptors in vivo and shows antipsychotic-like and procognitive effects in rodents

Increased baseline occupancy of D ₂ receptors by dopamine in schizophrenia

Anissa Abi‐Dargham, Janine Rodenhiser, David Printz et al. · Proceedings of the National Academy of Sciences · 2000 · 1K citations · Full text

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A targeted mutation of the D3 dopamine receptor gene is associated with hyperactivity in mice.

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Interactions of the Novel Antipsychotic Aripiprazole (OPC-14597) with Dopamine and Serotonin Receptor Subtypes

Cindy P. Lawler · Neuropsychopharmacology · 1999 · 411 citations · Full text

Medicine, Pharmacology, Psychiatry +14

Cariprazine (RGH-188), a Dopamine D3 Receptor-Preferring, D3/D2 Dopamine Receptor Antagonist–Partial Agonist Antipsychotic Candidate: In Vitro and Neurochemical Profile

Béla Kiss, Attila Horváth, Zsolt Némethy et al. · Journal of Pharmacology and Experimental Therapeutics · 2010 · 365 citations

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Pharmacological Actions of a Novel, High-Affinity, and Selective Human Dopamine D3 Receptor Antagonist, SB-277011-A

Stephen G. Taylor, Martyn Wood, Nigel Austin et al. · Journal of Pharmacology and Experimental Therapeutics · 2000 · 288 citations · Full text

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